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Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA

DNA topoisomerases are important targets in anticancer and antibacterial therapy because drugs can initiate cell death by stabilizing the transient covalent topoisomerase-DNA complex. In this study, we employed a method that uses CsCl density gradient centrifugation to separate unbound from DNA-boun...

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Détails bibliographiques
Auteurs principaux: Aedo, Sandra, Tse-Dinh, Yuk-Ching
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486612/
https://ncbi.nlm.nih.gov/pubmed/22869559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01182-12
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