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Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA

DNA topoisomerases are important targets in anticancer and antibacterial therapy because drugs can initiate cell death by stabilizing the transient covalent topoisomerase-DNA complex. In this study, we employed a method that uses CsCl density gradient centrifugation to separate unbound from DNA-boun...

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Main Authors: Aedo, Sandra, Tse-Dinh, Yuk-Ching
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486612/
https://ncbi.nlm.nih.gov/pubmed/22869559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01182-12
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