SbcCD-Mediated Processing of Covalent Gyrase-DNA Complex in Escherichia coli

Quinolones trap the covalent gyrase-DNA complex in Escherichia coli, leading to cell death. Processing activities for trapped covalent complex have not been characterized. A mutant strain lacking SbcCD nuclease activity was examined for both accumulation of gyrase-DNA complex and viability after qui...

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Bibliographic Details
Main Authors: Aedo, Sandra, Tse-Dinh, Yuk-Ching
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811449/
https://ncbi.nlm.nih.gov/pubmed/23917316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00130-13
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