Analysis of RuvABC and RecG Involvement in the Escherichia coli Response to the Covalent Topoisomerase-DNA Complex

Topoisomerases form a covalent enzyme-DNA intermediate after initial DNA cleavage. Trapping of the cleavage complex formed by type IIA topoisomerases initiates the bactericidal action of fluoroquinolones. It should be possible also to identify novel antibacterial lead compounds that act with a simil...

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Bibliographic Details
Main Authors: Sutherland, Jeanette H., Tse-Dinh, Yuk-Ching
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937393/
https://ncbi.nlm.nih.gov/pubmed/20601468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00350-10
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