Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog

Tallysomycins (TLMs) belong to the bleomycin (BLM) family of anticancer antibiotics and differ from the BLMs principally by the presence of a 4-amino-4,6-dideoxy-L-talose attached to C-41 of the TLM backbone as part of a glycosylcarbinolamide. To facilitate an understanding of the differences in ant...

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Bibliographic Details
Main Authors: Tao, Meifeng, Wang, Liyan, Wendt-Pienkowski, Evelyn, Zhang, Ningning, Yang, Dong, Galm, Ute, Coughlin, Jane M., Xu, Zhinan, Shen, Ben
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082865/
https://ncbi.nlm.nih.gov/pubmed/20094654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b918106g
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