Embryonic stem cell derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

Botulinum neurotoxins (BoNTs) inhibit cholinergic synaptic transmission by specifically cleaving proteins that are crucial for neurotransmitter exocytosis. Due to the lethality of these toxins, there are elevated concerns regarding their possible use as bioterrorism agents. Moreover, their widesprea...

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Hlavní autoři: Kiris, Erkan, Nuss, Jonathan E., Burnett, James C., Kota, Krishna P., Koh, Dawn C., Wanner, Laura M., Torres-Melendez, Edna, Gussio, Rick, Tessarollo, Lino, Bavari, Sina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081902/
https://ncbi.nlm.nih.gov/pubmed/21353660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2011.01.002
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