Synthesis and Evaluation of Radioligands for Imaging Brain Nociceptin/Orphanin FQ Peptide (NOP) Receptors with Positron Emission Tomography

Positron emission tomography (PET) coupled to an effective radioligand could provide an important tool for understanding possible links between neuropsychiatric disorders and brain NOP (nociceptin/orphanin FQ peptide) receptors. We sought to develop such a PET radioligand. High-affinity NOP ligands...

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Autori principali: Pike, Victor W., Rash, Karen S., Chen, Zhaogen, Pedregal, Concepción, Statnick, Michael A., Kimura, Yasuyuki, Hong, Jinsoo, Zoghbi, Sami S., Fujita, Masahiro, Toledo, Miguel A., Diaz, Nuria, Gackenheimer, Susan L., Tauscher, Johannes T., Barth, Vanessa N., Innis, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081360/
https://ncbi.nlm.nih.gov/pubmed/21438532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101487v
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