Brain and Whole-Body Imaging in Rhesus Monkeys of (11)C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors

Our laboratory developed (S)-3-(2′-fluoro-6′,7′-dihydrospiro [piperidine-4,4′-thieno[3,2-c]pyran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide ((11)C-NOP-1A), a new radioligand for the nociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (K(i), 0.15 nM) and appropriate lipophilicity (me...

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Main Authors: Kimura, Yasuyuki, Fujita, Masahiro, Hong, Jinsoo, Lohith, Talakad G., Gladding, Robert L., Zoghbi, Sami S., Tauscher, Johannes A., Goebl, Nancy, Rash, Karen S., Chen, Zhaogen, Pedregal, Concepcion, Barth, Vanessa N., Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216483/
https://ncbi.nlm.nih.gov/pubmed/21880575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.111.091181
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