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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
Caspase-8 has two opposing biological functions - it promotes cell death by triggering the extrinsic pathway of apoptosis, but also has a survival activity, as it is required for embryonic development1, T lymphocyte activation2, and resistance to necrosis induced by Tumor Necrosis Factor-α (TNF) and...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077893/ https://ncbi.nlm.nih.gov/pubmed/21368763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09852 |
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