Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

Caspase-8 has two opposing biological functions - it promotes cell death by triggering the extrinsic pathway of apoptosis, but also has a survival activity, as it is required for embryonic development1, T lymphocyte activation2, and resistance to necrosis induced by Tumor Necrosis Factor-α (TNF) and...

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Bibliografiske detaljer
Main Authors: Oberst, Andrew, Dillon, Christopher P., Weinlich, Ricardo, McCormick, Laura L., Fitzgerald, Patrick, Pop, Cristina, Hakem, Razq, Salvesen, Guy S., Green, Douglas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077893/
https://ncbi.nlm.nih.gov/pubmed/21368763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09852
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