Survival function of the FADD-CASPASE-8-cFLIP(L) complex

Mice deficient in caspase-8, FADD, or cFLIP, present defects in yolk sac vascularization and embryonic lethality at E10.5. Ablation of RIPK3, a kinase that promotes a form of necrotic cell death, has recently been shown to rescue embryonic lethality in caspase-8 deficient animals. Here we show that...

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Main Authors: Dillon, Christopher P., Oberst, Andrew, Weinlich, Ricardo, Janke, Laura J., Kang, Tae-Bong, Ben-Moshe, Tehila, Mak, Tak W., Wallach, David, Green, Douglas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366463/
https://ncbi.nlm.nih.gov/pubmed/22675671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.010
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