Protective roles for caspase-8 and cFLIP in adult homeostasis

Caspase-8 or cFLIP deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8(−/−), RIPK3(−/−), but not cFLIP(−/−), RIPK3(−/−), double-knockout animals develop normally, indicating that caspase-8 antagonizes the lethal effects of RIPK3 during development. Here w...

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Main Authors: Weinlich, Ricardo, Oberst, Andrew, Dillon, Christopher P., Janke, Laura J., Milasta, Sandra, Lukens, John R., Rodriguez, Diego A., Gurung, Prajwal, Savage, Chandra, Kanneganti, Thirumala D., Green, Douglas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843376/
https://ncbi.nlm.nih.gov/pubmed/24095739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.045
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