Protective roles for caspase-8 and cFLIP in adult homeostasis

Caspase-8 or cFLIP deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8(−/−), RIPK3(−/−), but not cFLIP(−/−), RIPK3(−/−), double-knockout animals develop normally, indicating that caspase-8 antagonizes the lethal effects of RIPK3 during development. Here w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Weinlich, Ricardo, Oberst, Andrew, Dillon, Christopher P., Janke, Laura J., Milasta, Sandra, Lukens, John R., Rodriguez, Diego A., Gurung, Prajwal, Savage, Chandra, Kanneganti, Thirumala D., Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843376/
https://ncbi.nlm.nih.gov/pubmed/24095739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.045
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados