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FLIP(L) induces caspase-8 activity in the absence of interdomain caspase-8 cleavage and alters substrate specificity
Caspase-8 is an initiator caspase that is activated by death receptors to initiate the extrinsic pathway of apoptosis. Caspase-8 activation involves dimerization and subsequent interdomain autoprocessing of caspase-8 zymogens, and recently published work has established that elimination of the autop...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4024219/ https://ncbi.nlm.nih.gov/pubmed/21235526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101738 |
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