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FLIP(L) induces caspase-8 activity in the absence of interdomain caspase-8 cleavage and alters substrate specificity

Caspase-8 is an initiator caspase that is activated by death receptors to initiate the extrinsic pathway of apoptosis. Caspase-8 activation involves dimerization and subsequent interdomain autoprocessing of caspase-8 zymogens, and recently published work has established that elimination of the autop...

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Main Authors: Pop, Cristina, Oberst, Andrew, Drag, Marcin, Van Raam, Bram J., Riedl, Stefan J., Green, Douglas R., Salvesen, Guy S.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024219/
https://ncbi.nlm.nih.gov/pubmed/21235526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101738
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