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An N-terminal Polybasic Domain and Cell Surface Localization Are Required for Mutant Prion Protein Toxicity

There is evidence that alterations in the normal physiological activity of PrP(C) contribute to prion-induced neurotoxicity. This mechanism has been difficult to investigate, however, because the normal function of PrP(C) has remained obscure, and there are no assays available to measure it. We rece...

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Main Authors: Solomon, Isaac H., Khatri, Natasha, Biasini, Emiliano, Massignan, Tania, Huettner, James E., Harris, David A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077669/
https://ncbi.nlm.nih.gov/pubmed/21385869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214973
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