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An N-terminal Polybasic Domain and Cell Surface Localization Are Required for Mutant Prion Protein Toxicity
There is evidence that alterations in the normal physiological activity of PrP(C) contribute to prion-induced neurotoxicity. This mechanism has been difficult to investigate, however, because the normal function of PrP(C) has remained obscure, and there are no assays available to measure it. We rece...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077669/ https://ncbi.nlm.nih.gov/pubmed/21385869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214973 |
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