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A Novel, Drug-based, Cellular Assay for the Activity of Neurotoxic Mutants of the Prion Protein
In prion diseases, the infectious isoform of the prion protein (PrP(Sc)) may subvert a normal, physiological activity of the cellular isoform (PrP(C)). A deletion mutant of the prion protein (Δ105–125) that produces a neonatal lethal phenotype when expressed in transgenic mice provides a window into...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844219/ https://ncbi.nlm.nih.gov/pubmed/19940127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064949 |
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