The Toxicity of a Mutant Prion Protein Is Cell-Autonomous, and Can Be Suppressed by Wild-Type Prion Protein on Adjacent Cells

Insight into the normal function of PrP(C), and how it can be subverted to produce neurotoxic effects, is provided by PrP molecules carrying deletions encompassing the conserved central region. The most neurotoxic of these mutants, Δ105–125 (called ΔCR), produces a spontaneous neurodegenerative illn...

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Bibliografiske detaljer
Main Authors: Biasini, Emiliano, Turnbaugh, Jessie A., Massignan, Tania, Veglianese, Pietro, Forloni, Gianluigi, Bonetto, Valentina, Chiesa, Roberto, Harris, David A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299791/
https://ncbi.nlm.nih.gov/pubmed/22428057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033472
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