The Toxicity of a Mutant Prion Protein Is Cell-Autonomous, and Can Be Suppressed by Wild-Type Prion Protein on Adjacent Cells

Insight into the normal function of PrP(C), and how it can be subverted to produce neurotoxic effects, is provided by PrP molecules carrying deletions encompassing the conserved central region. The most neurotoxic of these mutants, Δ105–125 (called ΔCR), produces a spontaneous neurodegenerative illn...

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Bibliographic Details
Main Authors: Biasini, Emiliano, Turnbaugh, Jessie A., Massignan, Tania, Veglianese, Pietro, Forloni, Gianluigi, Bonetto, Valentina, Chiesa, Roberto, Harris, David A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299791/
https://ncbi.nlm.nih.gov/pubmed/22428057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033472
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