Mutant Prion Protein Expression Is Associated with an Alteration of the Rab GDP Dissociation Inhibitor α (GDI)/Rab11 Pathway

The prion protein (PrP) is a glycosylphosphatidylinositol-anchored membrane glycoprotein that plays a vital role in prion diseases, a class of fatal neurodegenerative disorders of humans and animals. Approximately 20% of human prion diseases display autosomal dominant inheritance and are linked to m...

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Main Authors: Massignan, Tania, Biasini, Emiliano, Lauranzano, Eliana, Veglianese, Pietro, Pignataro, Mauro, Fioriti, Luana, Harris, David A., Salmona, Mario, Chiesa, Roberto, Bonetto, Valentina
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2010
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860234/
https://ncbi.nlm.nih.gov/pubmed/19996123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900271-MCP200
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