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Aggregated, Wild-Type Prion Protein Causes Neurological Dysfunction and Synaptic Abnormalities
The neurotoxic forms of the prion protein (PrP) that cause neurodegeneration in prion diseases remain to be conclusively identified. Considerable evidence points to the importance of noninfectious oligomers of PrP in the pathogenic process. In this study, we describe lines of Tg(WT) transgenic mice...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Society for Neuroscience
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646838/ https://ncbi.nlm.nih.gov/pubmed/19052217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3109-08.2008 |
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