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Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease
Transgenic Tg(PG14) mice express a mutant prion protein containing 14 octapeptide repeats, whose human homologue is associated with an inherited prion dementia. These mice develop a progressive neurological disorder characterized by ataxia and cerebellar atrophy, with massive apoptotic degeneration...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC544044/ https://ncbi.nlm.nih.gov/pubmed/15618403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406173102 |
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