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Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease

Transgenic Tg(PG14) mice express a mutant prion protein containing 14 octapeptide repeats, whose human homologue is associated with an inherited prion dementia. These mice develop a progressive neurological disorder characterized by ataxia and cerebellar atrophy, with massive apoptotic degeneration...

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Detalhes bibliográficos
Main Authors: Chiesa, Roberto, Piccardo, Pedro, Dossena, Sara, Nowoslawski, Lisa, Roth, Kevin A., Ghetti, Bernardino, Harris, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544044/
https://ncbi.nlm.nih.gov/pubmed/15618403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406173102
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