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Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease
Transgenic Tg(PG14) mice express a mutant prion protein containing 14 octapeptide repeats, whose human homologue is associated with an inherited prion dementia. These mice develop a progressive neurological disorder characterized by ataxia and cerebellar atrophy, with massive apoptotic degeneration...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544044/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15618403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406173102 |
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