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Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice
Familial prion diseases are due to dominantly inherited, germline mutations in the PRNP gene that encodes the prion protein (PrP). The cellular mechanism underlying the pathogenic effect of these mutations remains uncertain. To investigate whether pathogenic mutations impair a normal, physiological...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2007
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888682/ https://ncbi.nlm.nih.gov/pubmed/17510630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601726 |
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