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Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

Familial prion diseases are due to dominantly inherited, germline mutations in the PRNP gene that encodes the prion protein (PrP). The cellular mechanism underlying the pathogenic effect of these mutations remains uncertain. To investigate whether pathogenic mutations impair a normal, physiological...

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Bibliografiske detaljer
Main Authors: Li, Aimin, Piccardo, Pedro, Barmada, Sami J, Ghetti, Bernardino, Harris, David A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888682/
https://ncbi.nlm.nih.gov/pubmed/17510630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601726
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