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Neurotoxic Mutants of the Prion Protein Induce Spontaneous Ionic Currents in Cultured Cells
The mechanisms by which prions kill neurons and the role of the cellular prion protein in this process are enigmatic. Insight into these questions is provided by the neurodegenerative phenotypes of transgenic mice expressing prion protein (PrP) molecules with deletions of conserved amino acids in th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924115/ https://ncbi.nlm.nih.gov/pubmed/20573963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134619 |
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