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Donation of catalytic residues to RNA polymerase active center by transcription factor Gre

During transcription elongation, RNA polymerase (RNAP) occasionally loses its grip on the growing RNA end and backtracks on the DNA template. Prokaryotic Gre factors rescue the backtracked ternary elongating complex through stimulation of an intrinsic endonuclease activity, which removes the disenga...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sosunova, Ekaterina, Sosunov, Vasily, Kozlov, Maxim, Nikiforov, Vadim, Goldfarb, Alex, Mustaev, Arkady
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC307591/
https://ncbi.nlm.nih.gov/pubmed/14668436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536698100
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