Control of Transcriptional Fidelity by Active Center Tuning as Derived from RNA Polymerase Endonuclease Reaction

Precise transcription by cellular RNA polymerase requires the efficient removal of noncognate nucleotide residues that are occasionally incorporated. Mis-incorporation causes the transcription elongation complex to backtrack, releasing a single strand 3′-RNA segment bearing a noncognate residue, whi...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Sosunova, Ekaterina, Sosunov, Vasily, Epshtein, Vitaly, Nikiforov, Vadim, Mustaev, Arkady
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396497/
https://ncbi.nlm.nih.gov/pubmed/23283976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424002
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