Insights into RNA polymerase catalysis and adaptive evolution gained from mutational analysis of a locus conferring rifampicin resistance

S531 of Escherichia coli RNA polymerase (RNAP) β subunit is a part of RNA binding domain in transcription complex. While highly conserved, S531 is not involved in interactions within the transcription complex as suggested by X-ray analysis. To understand the basis for S531 conservation we performed...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Yurieva, Olga, Nikiforov, Vadim, O’Donnell, Michael, Mustaev, Arkady
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737076/
https://ncbi.nlm.nih.gov/pubmed/29036608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx813
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