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Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases
Eukaryotes require 3 DNA polymerases for normal replisome operations, DNA polymerases (Pol) α, delta and epsilon. Recent biochemical and structural studies support the asymmetric use of these polymerases on the leading and lagging strands. Pol epsilon interacts with the 11-subunit CMG helicase, form...
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| Gepubliceerd in: | Nucleus |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5039002/ https://ncbi.nlm.nih.gov/pubmed/27416113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1205774 |
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