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Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation
We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes. While bacteria and phage simply recruit polymerases to the fork, we find that suppression mechanisms are used to position th...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413876/ https://ncbi.nlm.nih.gov/pubmed/25871847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04988 |
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