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Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes. While bacteria and phage simply recruit polymerases to the fork, we find that suppression mechanisms are used to position th...

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Publicado en:eLife
Autores principales: Georgescu, Roxana E, Schauer, Grant D, Yao, Nina Y, Langston, Lance D, Yurieva, Olga, Zhang, Dan, Finkelstein, Jeff, O'Donnell, Mike E
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413876/
https://ncbi.nlm.nih.gov/pubmed/25871847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04988
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