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Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression
Single-molecule techniques are developed to examine mechanistic features of individual E. coli replisomes during synthesis of long DNA molecules. We find that single replisomes exhibit constant rates of fork movement, but the rates of different replisomes vary over a surprisingly wide range. Interes...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2726342/ https://ncbi.nlm.nih.gov/pubmed/19666586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906157106 |
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