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Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression

Single-molecule techniques are developed to examine mechanistic features of individual E. coli replisomes during synthesis of long DNA molecules. We find that single replisomes exhibit constant rates of fork movement, but the rates of different replisomes vary over a surprisingly wide range. Interes...

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Detalhes bibliográficos
Main Authors: Yao, Nina Y., Georgescu, Roxana E., Finkelstein, Jeff, O'Donnell, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726342/
https://ncbi.nlm.nih.gov/pubmed/19666586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906157106
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