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Revealing the role of the product metal in DNA polymerase β catalysis

DNA polymerases catalyze a metal-dependent nucleotidyl transferase reaction during extension of a DNA strand using the complementary strand as a template. The reaction has long been considered to require two magnesium ions. Recently, a third active site magnesium ion was identified in some DNA polym...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Perera, Lalith, Freudenthal, Bret D., Beard, William A., Pedersen, Lee G., Wilson, Samuel H.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389463/
https://ncbi.nlm.nih.gov/pubmed/28108654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1363
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