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Optimal and Variant Metal-Ion Routes in DNA Polymerase β’s Conformational Pathways

To interpret recent structures of the R283K mutant of human DNA repair enzyme DNA polymerase β (pol β) differing in the number of Mg(2+) ions, we apply transition path sampling (TPS) to assess the effect of differing ion placement on the transition from the open one-metal to the closed two-metal sta...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Li, Yunlang, Freudenthal, Bret D., Beard, William A., Wilson, Samuel H., Schlick, Tamar
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032070/
https://ncbi.nlm.nih.gov/pubmed/24511902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja412701f
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