Differing Conformational Pathways Before and After Chemistry for Insertion of dATP versus dCTP Opposite 8-OxoG in DNA Polymerase β

To elucidate how human DNA polymerase β (pol β) discriminates dATP from dCTP when processing 8-oxoguanine (8-oxoG), we analyze a series of dynamics simulations before and after the chemical step with dATP and dCTP opposite an 8-oxoG template started from partially open complexes of pol β. Analyses r...

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Bibliographic Details
Main Authors: Wang, Yanli, Reddy, Sujatha, Beard, William A., Wilson, Samuel H., Schlick, Tamar
Format: Artigo
Language:Inglês
Published: Biophysical Society 2007
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852361/
https://ncbi.nlm.nih.gov/pubmed/17293403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092106
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