How DNA Polymerase X Preferentially Accommodates Incoming dATP Opposite 8-Oxoguanine on the Template

The modified base 8-oxo-7,8-dihydro-2′-deoxyguanosine (oxoG) is a common DNA adduct produced by the oxidation of DNA by reactive oxygen species. Kinetic data reveal that DNA polymerase X (pol X) from the African swine fever virus incorporates adenine (dATP) opposite to oxoG with higher efficiency th...

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Detalhes bibliográficos
Main Authors: Sampoli Benítez, Benedetta, Barbati, Zachary R., Arora, Karunesh, Bogdanovic, Jasmina, Schlick, Tamar
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853083/
https://ncbi.nlm.nih.gov/pubmed/24314086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.10.014
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