Mismatched base pair simulations for ASFV Pol X/DNA complexes help interpret frequent G•G misincorporation

DNA polymerase X (pol X) from the African swine fever virus is a 174-amino acid repair polymerase that likely participates in a viral base excision repair mechanism, characterized by low fidelity. Surprisingly, pol X’s insertion rate of the G•G mispair is comparable to that of the four Watson-Crick...

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Huvudupphovsmän: Sampoli Benítez, Benedetta A., Arora, Karunesh, Balistreri, Lisa, Schlick, Tamar
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644343/
https://ncbi.nlm.nih.gov/pubmed/18955064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.025
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