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Fidelity Discrimination in DNA polymerase β: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair
Understanding fidelity — the faithful replication or repair of DNA by polymerases — requires tracking of structural and energetic changes involved, including the elusive transient intermediates, for nucleotide incorporation at the template/primer DNA junction. We report using path sampling simulatio...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2625286/ https://ncbi.nlm.nih.gov/pubmed/16173754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja052623o |
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