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Fidelity Discrimination in DNA polymerase β: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair

Understanding fidelity — the faithful replication or repair of DNA by polymerases — requires tracking of structural and energetic changes involved, including the elusive transient intermediates, for nucleotide incorporation at the template/primer DNA junction. We report using path sampling simulatio...

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Detalhes bibliográficos
Main Authors: Radhakrishnan, Ravi, Schlick, Tamar
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2625286/
https://ncbi.nlm.nih.gov/pubmed/16173754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja052623o
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