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Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase β's closing
Our application of transition path sampling to a complex biomolecular system in explicit solvent, the closing transition of DNA polymerase β, unravels atomic and energetic details of the conformational change that precedes the chemical reaction of nucleotide incorporation. The computed reaction prof...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC395907/ https://ncbi.nlm.nih.gov/pubmed/15069184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308585101 |
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