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Modeling DNA Polymerase μ Motions: Subtle Transitions before Chemistry

To investigate whether an open-to-closed transition before the chemical step and induced-fit mechanism exist in DNA polymerase μ (pol μ), we analyze a series of molecular-dynamics simulations with and without the incoming nucleotide in various forms, including mutant systems, based on pol μ's c...

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Detalhes bibliográficos
Main Authors: Li, Yunlang, Schlick, Tamar
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980731/
https://ncbi.nlm.nih.gov/pubmed/21081096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.056
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