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Modeling DNA Polymerase μ Motions: Subtle Transitions before Chemistry
To investigate whether an open-to-closed transition before the chemical step and induced-fit mechanism exist in DNA polymerase μ (pol μ), we analyze a series of molecular-dynamics simulations with and without the incoming nucleotide in various forms, including mutant systems, based on pol μ's c...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Biophysical Society
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980731/ https://ncbi.nlm.nih.gov/pubmed/21081096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.056 |
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