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Sequential Side-Chain Residue Motions Transform the Binary into the Ternary State of DNA Polymerase λ
The nature of conformational transitions in DNA polymerase λ (pol λ), a low-fidelity DNA repair enzyme in the X-family that fills short nucleotide gaps, is investigated. Specifically, to determine whether pol λ has an induced-fit mechanism and open-to-closed transition before chemistry, we analyze a...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Biophysical Society
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1614482/ https://ncbi.nlm.nih.gov/pubmed/16920835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092080 |
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