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The Relationship Between Conformational Changes in Pol λ’s Active Site Upon Binding Incorrect Nucleotides and Mismatch Incorporation Rates
The correct replication and repair of DNA is critical for a cell’s survival. Here we investigate the fidelity of mammalian DNA polymerase λ (pol λ) utilizing dynamics simulation of the enzyme bound to incorrect incoming nucleotides including A:C, A:G, A(syn):G, A:A, A(syn):A, and T:G, all of which e...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751813/ https://ncbi.nlm.nih.gov/pubmed/19572669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp903172x |
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