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Distinct energetics and closing pathways for DNA polymerase β with 8-oxoG template and different incoming nucleotides

BACKGROUND: 8-Oxoguanine (8-oxoG) is a common oxidative lesion frequently encountered by DNA polymerases such as the repair enzyme DNA polymerase β (pol β). To interpret in atomic and energetic detail how pol β processes 8-oxoG, we apply transition path sampling to delineate closing pathways of pol...

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Bibliographic Details
Main Authors: Wang, Yanli, Schlick, Tamar
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1819382/
https://ncbi.nlm.nih.gov/pubmed/17313689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-7
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