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Distinct energetics and closing pathways for DNA polymerase β with 8-oxoG template and different incoming nucleotides
BACKGROUND: 8-Oxoguanine (8-oxoG) is a common oxidative lesion frequently encountered by DNA polymerases such as the repair enzyme DNA polymerase β (pol β). To interpret in atomic and energetic detail how pol β processes 8-oxoG, we apply transition path sampling to delineate closing pathways of pol...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1819382/ https://ncbi.nlm.nih.gov/pubmed/17313689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-7 |
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