Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion

BACKGROUND: Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair with an...

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Main Authors: Carpio, Rodrigo Vasquez-Del, Silverstein, Timothy D., Lone, Samer, Swan, Michael K., Choudhury, Jayati R., Johnson, Robert E., Prakash, Satya, Prakash, Louise, Aggarwal, Aneel K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686167/
https://ncbi.nlm.nih.gov/pubmed/19492058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005766
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