Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer

Exposure of DNA to UV radiation causes covalent linkages between adjacent pyrimidines. The most common lesion found in DNA from these UV-induced linkages is the cis-syn cyclobutane pyrimidine dimer (CPD). Human DNA polymerase κ (Polκ), a member of the Y-family of DNA polymerases, is unable to insert...

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Главные авторы: Carpio, Rodrigo Vasquez-Del, Silverstein, Timothy D., Lone, Samer, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093752/
https://ncbi.nlm.nih.gov/pubmed/21354175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.02.042
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