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Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase η

DNA polymerase η (Polη) has the unique ability to replicate through UV-light-induced cyclobutane pyrimidine dimers. Here we use pre-steady-state kinetic analyses to examine the mechanism of nucleotide incorporation opposite a cis-syn thymine-thymine (TT) dimer and an identical nondamaged sequence by...

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Detalhes bibliográficos
Main Authors: Washington, M. Todd, Prakash, Louise, Prakash, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC218718/
https://ncbi.nlm.nih.gov/pubmed/14527996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2134223100
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