PKCα Mediates β-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia

Nephrin, the key molecule of the glomerular slit diaphragm, is expressed on the surface of podocytes and is critical in preventing albuminuria. In diabetes, hyperglycemia leads to the loss of surface expression of nephrin and causes albuminuria. Here, we report a mechanism that can explain this phen...

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Sonraí Bibleagrafaíochta
Main Authors: Quack, Ivo, Woznowski, Magdalena, Potthoff, Sebastian A., Palmer, Romy, Königshausen, Eva, Sivritas, Sema, Schiffer, Mario, Stegbauer, Johannes, Vonend, Oliver, Rump, Lars Christian, Sellin, Lorenz
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075643/
https://ncbi.nlm.nih.gov/pubmed/21321125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204024
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