PKCα Mediates β-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia

Nephrin, the key molecule of the glomerular slit diaphragm, is expressed on the surface of podocytes and is critical in preventing albuminuria. In diabetes, hyperglycemia leads to the loss of surface expression of nephrin and causes albuminuria. Here, we report a mechanism that can explain this phen...

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Détails bibliographiques
Auteurs principaux: Quack, Ivo, Woznowski, Magdalena, Potthoff, Sebastian A., Palmer, Romy, Königshausen, Eva, Sivritas, Sema, Schiffer, Mario, Stegbauer, Johannes, Vonend, Oliver, Rump, Lars Christian, Sellin, Lorenz
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075643/
https://ncbi.nlm.nih.gov/pubmed/21321125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204024
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