PKCα Mediates β-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia

Nephrin, the key molecule of the glomerular slit diaphragm, is expressed on the surface of podocytes and is critical in preventing albuminuria. In diabetes, hyperglycemia leads to the loss of surface expression of nephrin and causes albuminuria. Here, we report a mechanism that can explain this phen...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Quack, Ivo, Woznowski, Magdalena, Potthoff, Sebastian A., Palmer, Romy, Königshausen, Eva, Sivritas, Sema, Schiffer, Mario, Stegbauer, Johannes, Vonend, Oliver, Rump, Lars Christian, Sellin, Lorenz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2011
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075643/
https://ncbi.nlm.nih.gov/pubmed/21321125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204024
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