PKCα Mediates β-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia

Nephrin, the key molecule of the glomerular slit diaphragm, is expressed on the surface of podocytes and is critical in preventing albuminuria. In diabetes, hyperglycemia leads to the loss of surface expression of nephrin and causes albuminuria. Here, we report a mechanism that can explain this phen...

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Hlavní autoři: Quack, Ivo, Woznowski, Magdalena, Potthoff, Sebastian A., Palmer, Romy, Königshausen, Eva, Sivritas, Sema, Schiffer, Mario, Stegbauer, Johannes, Vonend, Oliver, Rump, Lars Christian, Sellin, Lorenz
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075643/
https://ncbi.nlm.nih.gov/pubmed/21321125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204024
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