A mutant HpaII methyltransferase functions as a mutator enzyme.

DNA (cytosine-5)-methyltransferases can cause deamination of cytosine when the cofactor S-adenosylmethionine (AdoMet) is limiting and thus function as sequence-specific C-->U mutator enzymes. Here we explored whether mutations causing inactivation of the cofactor binding activity of the HpaII met...

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Bibliografiske detaljer
Main Authors: Shen, J C, Zingg, J M, Yang, A S, Schmutte, C, Jones, P A
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC307380/
https://ncbi.nlm.nih.gov/pubmed/7501446
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