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Functional analysis of Gln-237 mutants of HhaI methyltransferase.
When the HhaI (cytosine-5) methyltransferase (M.HhaI) binds DNA it causes the target cytosine to be flipped 180 degrees out of the helix. The space becomes occupied by two amino acids, Ser-87 and Gln-237, which enter the helix from opposite sides and form a hydrogen bond to each other. Gln-237 may b...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1995
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306729/ https://ncbi.nlm.nih.gov/pubmed/7899082 |
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