A mutant HpaII methyltransferase functions as a mutator enzyme.

DNA (cytosine-5)-methyltransferases can cause deamination of cytosine when the cofactor S-adenosylmethionine (AdoMet) is limiting and thus function as sequence-specific C-->U mutator enzymes. Here we explored whether mutations causing inactivation of the cofactor binding activity of the HpaII methyl...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Shen, J C, Zingg, J M, Yang, A S, Schmutte, C, Jones, P A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1995
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7501446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.21.4275
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