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A mutant HpaII methyltransferase functions as a mutator enzyme.
DNA (cytosine-5)-methyltransferases can cause deamination of cytosine when the cofactor S-adenosylmethionine (AdoMet) is limiting and thus function as sequence-specific C-->U mutator enzymes. Here we explored whether mutations causing inactivation of the cofactor binding activity of the HpaII met...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
1995
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| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7501446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.21.4275 |
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